NGS

Arabidopsis BORDER proteins put the breaks on RNA polymerase II elongation

While studying the regulation of flowering in Arabidopsis thaliana, we uncovered a family of proteins that play multifaceted roles in gene expression via a common mechanism: slowing down the progression of RNA polymeraseII

Bioinformatics and Biostatistics

Tools for the analysis and integration of high throughput data

BORDER proteins protect expression of neighboring genes by promoting 3' Pol II pausing in plants

Ensuring that one gene's transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms …

A family of negative transcription elongation factors protects the genome of Arabidopsis thaliana from transcriptional interferences

BDR negative elongation factors protect the genome from transcriptional interferences

A family of negative transcription elongation factors regulates defense response genes and protects the genome of A. thaliana from transcriptional interferences

BDR negative elongation factors protect the genome from transcriptional interferences

Core bioconductor packages for NGS data analysis