- The 7SK snRNA is dispensable for cell proliferation under standard growth conditions - After UV exposure, 7SK/P-TEFb is needed for proper stress response and cell survival - P-TEFb extracted from 7SK/P-TEFb triggers UV-induced general RNAPII pause release - P-TEFb from 7SK/P-TEFb supports activation of important UV-responsive genes
Ensuring that one gene's transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms …
Visit [GeneNeighborhood on github](https://github.com/pgpmartin/GeneNeighborhood)
Generating random genome annotations For different purposes, I often need to create random gene/features annotations. I usually need these annotations as a GRanges object (see the GenomicRanges package).
I searched a bit on the internet but couldn’t really find what I was looking for.