transcription

Arabidopsis BORDER proteins put the breaks on RNA polymerase II elongation

While studying the regulation of flowering in Arabidopsis thaliana, we uncovered a family of proteins that play multifaceted roles in gene expression via a common mechanism: slowing down the progression of RNA polymeraseII

Widespread premature transcription termination of Arabidopsis thaliana NLR genes by the spen protein FPA

Genes involved in disease resistance are some of the fastest evolving and most diverse components of genomes. Large numbers of nucleotide-binding, leucine-rich repeat (NLR) genes are found in plant genomes and are required for disease resistance. …

The 7SK/P-TEFb snRNP controls ultraviolet radiation-induced transcriptional reprogramming

- The 7SK snRNA is dispensable for cell proliferation under standard growth conditions - After UV exposure, 7SK/P-TEFb is needed for proper stress response and cell survival - P-TEFb extracted from 7SK/P-TEFb triggers UV-induced general RNAPII pause release - P-TEFb from 7SK/P-TEFb supports activation of important UV-responsive genes

Chromatin and Transcription

Transcription by RNA polymerase II in the context of chromatin

Food toxicology

Understanding the mechanisms and impacts of food contaminants on biological systems

Nuclear receptors

Regulation of gene expression in the liver by nuclear receptors

BORDER proteins protect expression of neighboring genes by promoting 3' Pol II pausing in plants

Ensuring that one gene's transcription does not inappropriately affect the expression of its neighbors is a fundamental challenge to gene regulation in a genomic context. In plants, which lack homologs of animal insulator proteins, the mechanisms …

A family of negative transcription elongation factors protects the genome of Arabidopsis thaliana from transcriptional interferences

BDR negative elongation factors protect the genome from transcriptional interferences

A family of negative transcription elongation factors regulates defense response genes and protects the genome of A. thaliana from transcriptional interferences

BDR negative elongation factors protect the genome from transcriptional interferences