PG Martin

Latest

• NO synthesis from arginine is favored by alpha-linolenic acid in mice fed a high-fat diet
• Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
• The Extent of mRNA Editing Is Limited in Chicken Liver and Adipose, but Impacted by Tissular Context, Genotype, Age, and Feeding as Exemplified with a Conserved Edited Site in COG3.
• Exploring transcriptomic diversity in muscle revealed that cellular signaling pathways mainly differentiate five Western porcine breeds.
• Muscle transcriptomic investigation of late fetal development identifies candidate genes for piglet maturity.
• Impairment of adipose tissue in Prader-Willi syndrome rescued by growth hormone treatment.
• The miR-379/miR-410 cluster at the imprinted Dlk1-Dio3 domain controls neonatal metabolic adaptation.
• Changes in intestinal glucocorticoid sensitivity in early life shape the risk of epithelial barrier defect in maternal-deprived rats.
• Chromatin immunoprecipitation indirect peaks highlight long-range interactions of insulator proteins and Pol II pausing.
• Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.
• The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.
• A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARalpha.
• CYP450-dependent biotransformation of the insecticide fipronil into fipronil sulfone can mediate fipronil-induced thyroid disruption in rats.
• Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver.
• A role for PPARalpha in the regulation of arginine metabolism and nitric oxide synthesis.
• P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice.
• Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis.
• Consequences of PPAR(alpha) Invalidation on Glutathione Synthesis: Interactions with Dietary Fatty Acids.
• A minimal model for hepatic fatty acid balance during fasting: application to PPAR alpha-deficient mice.
• FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.
• Clustering time-series gene expression data using smoothing spline derivatives.
• The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.
• Effects of illicit dexamethasone upon hepatic drug metabolizing enzymes and related transcription factors mRNAs and their potential use as biomarkers in cattle.
• Impact of oral bisphenol A at reference doses on intestinal barrier function and sex differences after perinatal exposure in rats.
• FAN stimulates TNF(alpha)-induced gene expression, leukocyte recruitment, and humoral response.
• Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates.
• Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach.
• Sparse canonical methods for biological data integration: application to a cross-platform study.
• Effects of dexamethasone, administered for growth promoting purposes, upon the hepatic cytochrome P450 3A expression in the veal calf.
• Transcriptional regulation of hepatic fatty acid metabolism.
• Cytochrome P450 inhibition profile in liver of veal calves administered a combination of 17beta-estradiol, clenbuterol, and dexamethasone for growth-promoting purposes.
• High potency of bioactivation of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in mouse colon epithelial cells with Apc(Min) mutation.
• PPARalpha transcriptionally induces AhR expression in Caco-2, but represses AhR pro-inflammatory effects.
• Fumonisin B1 exposure and its selective effect on porcine jejunal segment: sphingolipids, glycolipids and trans-epithelial passage disturbance.
• Novel aspects of PPARalpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study.
• Influence of dyslipidemia on moxidectin distribution in plasma lipoproteins and on its pharmacokinetics.
• Transcriptional modulations by RXR agonists are only partially subordinated to PPARalpha signaling and attest additional, organ-specific, molecular cross-talks.
• Phenylbutyrate up-regulates the adrenoleukodystrophy-related gene as a nonclassical peroxisome proliferator.