H Guillou

Latest

• Dietary oleic acid regulates hepatic lipogenesis through a liver X receptor-dependent signaling
• Adverse effects of long-term exposure to bisphenol A during adulthood leading to hyperglycaemia and hypercholesterolemia in mice.
• Essential fatty acids deficiency promotes lipogenic gene expression and hepatic steatosis through the liver X receptor.
• A systems biology approach to the hepatic role of the oxysterol receptor LXR in the regulation of lipogenesis highlights a cross-talk with PPARalpha.
• Low doses of bisphenol A induce gene expression related to lipid synthesis and trigger triglyceride accumulation in adult mouse liver.
• P-glycoprotein dysfunction contributes to hepatic steatosis and obesity in mice.
• Liver X Receptor: an oxysterol sensor and a major player in the control of lipogenesis.
• A minimal model for hepatic fatty acid balance during fasting: application to PPAR alpha-deficient mice.
• The key roles of elongases and desaturases in mammalian fatty acid metabolism: Insights from transgenic mice.
• Di-(2-ethylhexyl)-phthalate (DEHP) activates the constitutive androstane receptor (CAR): a novel signalling pathway sensitive to phthalates.
• Identification of potential mechanisms of toxicity after di-(2-ethylhexyl)-phthalate (DEHP) adult exposure in the liver using a systems biology approach.
• Transcriptional regulation of hepatic fatty acid metabolism.
• Novel aspects of PPARalpha-mediated regulation of lipid and xenobiotic metabolism revealed through a nutrigenomic study.
• Comparative effect of fenofibrate on hepatic desaturases in wild-type and peroxisome proliferator-activated receptor alpha-deficient mice.